1052515-91-9
1052515-91-9
Chemical Structure
VU0134992 hydrochloride
- CAS No.: 1052515-91-9
- Formula:C20H32BrClN2O2
- Molecular Weight:447.84
IUPAC Name: 2-(2-bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide hydrochloride
InChIKey: QXKQUPCNSXWIDX-UHFFFAOYSA-N
SMILES: O=C(NC1CC(C)(C)NC(C)(C)C1)COC2=CC=C(C(C)C)C=C2Br.[H]Cl
Biological Activity: VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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VU0134992 hydrochloride | 98.49% | VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV. | ||||||||||||||||||||
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