105496-35-3
Chemical Structure
LY 190388
- CAS No.: 105496-35-3
- Formula:C30H41N5O7S
- Molecular Weight:615.74
IUPAC Name: ((S)-2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-3-mercapto-3-methylbutanoyl)glycyl-L-phenylalanyl-D-valine
InChIKey: PMSAWKRESCKOJT-HFOXQMJASA-N
SMILES: CC([C@@H](NC([C@@H](NC(CNC([C@H](NC([C@@H](N)CC1=CC=C(O)C=C1)=O)C(S)(C)C)=O)=O)CC2=CC=CC=C2)=O)C(O)=O)C
Biological Activity: LY 190388 is a penicillamine-containing enkefa peptide analog with μ receptor agonist activity. LY 190388 showed analgesic effect in inhibiting the writhing response in mice after intracerebroventricular administration. The analgesic effect of LY 190388 is not caused by its δ receptor agonist action, but by its μ receptor agonist activity. When LY 190388 is used together with the δ receptor antagonist ICI 174864, an additive analgesic effect is produced[1].
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LY 190388 | LY 190388 is a penicillamine-containing enkefa peptide analog with μ receptor agonist activity. LY 190388 showed analgesic effect in inhibiting the writhing response in mice after intracerebroventricular administration. The analgesic effect of LY 190388 is not caused by its δ receptor agonist action, but by its μ receptor agonist activity. When LY 190388 is used together with the δ receptor antagonist ICI 174864, an additive analgesic effect is produced. | |||||||||||||||||||||
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