105611-68-5
Chemical Structure
Ebiratide
Synonym(s): HOE-427 free base
- CAS No.: 105611-68-5
- Formula:C48H73N11O10S
- Molecular Weight:996.23
IUPAC Name: (4S,7S,10S,13R)-7-((1H-imidazol-5-yl)methyl)-23-amino-15-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-4-((S)-2-amino-4-(methylsulfonyl)butanamido)-13-(4-aminobutyl)-10-benzyl-5,8,11,14-tetraoxo-6,9,12,15-tetraazatricosan-1-oic acid
InChIKey: UMGYZFNFUVMLKV-BDPXDZDXSA-N
SMILES: NCCCCCCCCNC([C@H](CC1=CC=CC=C1)NC([C@@H](CCCCN)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](N)CCS(C)(=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O
Biological Activity: Ebiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain[1][2].
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Ebiratide | Ebiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain. | |||||||||||||||||||||
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References
- [1]. Hock FJ, et al., Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats. Peptides. 1988 May-Jun;9(3):575-81. [Content Brief]
- [2]. G Wiemer, et al. Neurochemical effects of the synthetic ACTH4-9-analog Hoe 427 (Ebiratide) in rat brain. Peptides. 1988 Sep-Oct;9(5):1081-7. [Content Brief]
