105618-03-9
Chemical Structure
(S)-(-)-Felodipine
- CAS No.: 105618-03-9
- Formula:C18H19Cl2NO4
- Molecular Weight:384.25
IUPAC Name: 3-ethyl 5-methyl (S)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey: RZTAMFZIAATZDJ-HNNXBMFYSA-N
SMILES: CCOC(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=C(C(Cl)=CC=C2)Cl)=O
Biological Activity: (S)-(-)-Felodipine is a S-enantiomer of Felodipine. (S)-(-)-Felodipine is an antihypertensive agent. Felodipine is a 1,4-dihydropyridine derivative and a vasoselective calcium antagonist. Felodipine can prevent the activation of the vascular effector cells and interfere with the contractile process in vitro. Felodipine lowers mean arterial blood pressure by 20% in dog model. (S)-(-)-Felodipine shows high metabolic rate in rat and dog liver microsomes[1][2].
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(S)-(-)-Felodipine | (S)-(-)-Felodipine is a S-enantiomer of Felodipine. (S)-(-)-Felodipine is an antihypertensive agent. Felodipine is a 1,4-dihydropyridine derivative and a vasoselective calcium antagonist. Felodipine can prevent the activation of the vascular effector cells and interfere with the contractile process in vitro. Felodipine lowers mean arterial blood pressure by 20% in dog model. (S)-(-)-Felodipine shows high metabolic rate in rat and dog liver microsomes. | |||||||||||||||||||||
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References
- [1]. Eriksson, U. G., et al., (1991). Stereoselective metabolism of felodipine in liver microsomes from rat, dog, and human. Drug metabolism and disposition: the biological fate of chemicals, 19(5), 889-894. [Content Brief]
- [2]. Ljung, B. Vascular Selectivity of Felodipine. Drugs 29 (Suppl 2), 46-58 (1985).
