105618-26-6
Chemical Structure
nor-Binaltorphimine
Synonym(s): Norbinaltorphimine; NorBNI
- CAS No.: 105618-26-6
- Formula:C40H43N3O6
- Molecular Weight:661.79
InChIKey: APSUXPSYBJVPPS-YAUKWVCOSA-N
SMILES: O[C@]12[C@]34[C@](OC5=C(O)C=CC(C[C@@]2([H])N(CC4)CC6CC6)=C53)([H])C7=C(C8=C([C@@]9([H])[C@]%10%11[C@@](C8)([C@](CC%12=C%11C(O9)=C(C=C%12)O)([H])N(CC%10)CC%13CC%13)O)N7)C1
Biological Activity: nor-Binaltorphimine (Norbinaltorphimine; NorBNI) is a selective, long-acting competitive antagonist of the κ-opioid receptor. nor-Binaltorphimine blocks κ-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation. nor-Binaltorphimine suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying κ-opioid receptor-agonist interactions. nor-Binaltorphimine is applicable to research related to neurological disorders such as pain[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
nor-Binaltorphimine | 99.42% | nor-Binaltorphimine (Norbinaltorphimine; NorBNI) is a selective, long-acting competitive antagonist of the κ-opioid receptor. nor-Binaltorphimine blocks κ-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation. nor-Binaltorphimine suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying κ-opioid receptor-agonist interactions. nor-Binaltorphimine is applicable to research related to neurological disorders such as pain. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Spanagel R, et al. Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes. Eur J Pharmacol. 1994;264(2):157-162. [Content Brief]
- [2]. Jaw SP, et al. Effects of nor-binaltorphimine on butorphanol dependence. Eur J Pharmacol. 1993;239(1-3):133-140. [Content Brief]
- [3]. Portoghese PS, et al. Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists. Life Sci. 1987 Mar 30;40(13):1287-92. [Content Brief]
