1059070-10-8
1059070-10-8
Chemical Structure
DSR-6434
- CAS No.: 1059070-10-8
- Formula:C19H28N8O2
- Molecular Weight:400.48
IUPAC Name: 6-amino-2-(butylamino)-9-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)methyl)-7,9-dihydro-8H-purin-8-one
InChIKey: SSZHESNDOMBSRV-UHFFFAOYSA-N
SMILES: O=C1N(C2=NC(NCCCC)=NC(N)=C2N1)CC3=CN=C(OCCN(C)C)C=C3
Biological Activity: DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively. DSR-6434 has a strong antitumor effect[1][2].
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DSR-6434 | 99.32% | DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively. DSR-6434 has a strong antitumor effect. | ||||||||||||||||||||
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DSR-6434 (Standard) | ≥98% | DSR-6434 (Standard) is the analytical standard of DSR-6434 (HY-110120). This product is intended for research and analytical applications. DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively. DSR-6434 has a strong antitumor effect. | ||||||||||||||||||||
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References
- [1]. Nakamura T, et al. Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg Med Chem Lett. 2013 Feb 1;23(3):669-72. [Content Brief]
- [2]. Adlard AL, et al. A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int J Cancer. 2014 Aug 15;135(4):820-9. [Content Brief]
