105955-11-1
Chemical Structure
N-Oleoyldopamine
Synonym(s): OLDA
- CAS No.: 105955-11-1
- Formula:C26H43NO3
- Molecular Weight:417.62
IUPAC Name: N-(3,4-dihydroxyphenethyl)oleamide
InChIKey: QQBPLXNESPTPNU-KTKRTIGZSA-N
SMILES: CCCCCCCC/C=C\CCCCCCCC(NCCC1=CC=C(O)C(O)=C1)=O
Biological Activity: N-Oleoyldopamine (OLDA) is an orally active TRPV1 activator and 5-LOX inhibitor with blood-brain barrier permeability. N-Oleoyldopamine excites histaminergic neurons in the tuberomammillary nucleus via a dopamine receptor mechanism, a process independent of TRPV1 and cannabinoid receptors. On one hand, N-Oleoyldopamine promotes the release of insulin and glucose-dependent insulinotropic polypeptide through a GPR119-dependent pathway to improve glucose tolerance; on the other hand, N-Oleoyldopamine improves left ventricular function and reduces myocardial infarction size by triggering the release of substance P and calcitonin gene-related peptide. N-Oleoyldopamine is used in studies related to glycemic abnormalities and myocardial ischemia-reperfusion injury[1][2][3].
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N-Oleoyldopamine | 99.47% | N-Oleoyldopamine (OLDA) is an orally active TRPV1 activator and 5-LOX inhibitor with blood-brain barrier permeability. N-Oleoyldopamine excites histaminergic neurons in the tuberomammillary nucleus via a dopamine receptor mechanism, a process independent of TRPV1 and cannabinoid receptors. On one hand, N-Oleoyldopamine promotes the release of insulin and glucose-dependent insulinotropic polypeptide through a GPR119-dependent pathway to improve glucose tolerance; on the other hand, N-Oleoyldopamine improves left ventricular function and reduces myocardial infarction size by triggering the release of substance P and calcitonin gene-related peptide. N-Oleoyldopamine is used in studies related to glycemic abnormalities and myocardial ischemia-reperfusion injury. | ||||||||||||||||||||
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N-Oleoyldopamine (Standard) | ≥98% | N-Oleoyldopamine (Standard) is the analytical standard of N-Oleoyldopamine (HY-108448). This product is intended for research and analytical applications. N-Oleoyldopamine (OLDA) is a product of condensation of oleic acid and dopamine (DA) and an endogenous TRPV1 selective agonist. N-Oleoyldopamine (OLDA) can crosses the blood-brain barrier. N-oleoyl-dopamine protects the heart against ischemia-reperfusion injury via activation of TRPV1. | ||||||||||||||||||||
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References
- [1]. De Luca R, et al. Mechanisms of N-oleoyldopamine activation of central histaminergic neurons. Neuropharmacology. 2018;143:327-338. [Content Brief]
- [2]. Chu ZL, et al. N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119. Mol Endocrinol. 2010;24(1):161-170. [Content Brief]
- [3]. Zhong B, et al. N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1. Am J Physiol Heart Circ Physiol. 2008;295(2):H728-H735. [Content Brief]
