106134-33-2
106134-33-2
Chemical Structure
Ro 22-9194
- CAS No.: 106134-33-2
- Formula:C19H27Cl2N3O
- Molecular Weight:384.34
IUPAC Name: 2-amino-N-(2,6-dimethylphenyl)-N-(3-(pyridin-3-yl)propyl)propanamide dihydrochloride
InChIKey: VLIYADXYDUEILX-UHFFFAOYSA-N
SMILES: CC(N)C(N(C1=C(C)C=CC=C1C)CCCC2=CC=CN=C2)=O.[H]Cl.[H]Cl
Biological Activity: Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action[1][2].
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Ro 22-9194 | Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action. | |||||||||||||||||||||
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References
- [1]. M Murakami, et al. Cardiovascular effects of 2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide dihydrochloride (Ro 22-9194) in the isolated, cross-perfused atrium of the dog. Jpn Heart J. 1990 Sep;31(5):731-9. [Content Brief]
- [2]. I Kodama, et al. Electropharmacology of Ro 22-9194, a new antiarrhythmic agent. Gen Pharmacol. 1996 Jul;27(5):755-60. [Content Brief]
