1062136-15-5
Chemical Structure
2',2'‐Difluorodeoxyuridine 5'‐triphosphate
Synonym(s): dFdUTP
- CAS No.: 1062136-15-5
- Formula:C9H13F2N2O14P3
- Molecular Weight:504.12
InChIKey: ZSLPPDIWQJYAFN-QPPQHZFASA-N
SMILES: O=C(C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)NC1=O
Biological Activity: 2',2'-Difluorodeoxyuridine 5'-triphosphate (dFdUTP) is the intracellular phosphorylated metabolite of dFdU (HY-138253), which in turn is the deaminated metabolite of Gemcitabine (HY-17026). 2',2'-Difluorodeoxyuridine 5'-triphosphate incorporates into DNA and RNA, contributing to Gemcitabine-associated cytotoxicity and hepatotoxicity. 2',2'-Difluorodeoxyuridine 5'-triphosphate accumulates in the liver and kidneys of mice, and is detectable in mouse plasma and urine. 2',2'-Difluorodeoxyuridine 5'-triphosphate can be used in the research of breast cancer and non-small cell lung cancer[1][2][3].
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2',2'‐Difluorodeoxyuridine 5'‐triphosphate | 2',2'-Difluorodeoxyuridine 5'-triphosphate (dFdUTP) is the intracellular phosphorylated metabolite of dFdU (HY-138253), which in turn is the deaminated metabolite of Gemcitabine (HY-17026). 2',2'-Difluorodeoxyuridine 5'-triphosphate incorporates into DNA and RNA, contributing to Gemcitabine-associated cytotoxicity and hepatotoxicity. 2',2'-Difluorodeoxyuridine 5'-triphosphate accumulates in the liver and kidneys of mice, and is detectable in mouse plasma and urine. 2',2'-Difluorodeoxyuridine 5'-triphosphate can be used in the research of breast cancer and non-small cell lung cancer. | |||||||||||||||||||||
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References
- [1]. Derissen EJB, et al. Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides. British journal of clinical pharmacology. 2018 Jun;84(6):1279-1289. [Content Brief]
- [2]. Benyumov A, et al. Combinatorial pharmacologic effects of gemcitabine and its metabolite dFdU. ChemMedChem. 2011 Mar 07;6(3):457-64. [Content Brief]
- [3]. Veltkamp SA. Clinical pharmacological and translational research on novel formulations of anticancer drugs. 2008.
