107000-34-0
Chemical Structure
Zanoterone
Synonym(s): WIN 49596
- CAS No.: 107000-34-0
- Formula:C23H32N2O3S
- Molecular Weight:416.58
IUPAC Name: (1R,3aS,3bR,5aS,10aS,10bS,12aS)-1-ethynyl-10a,12a-dimethyl-8-(methylsulfonyl)-1,2,3,3a,3b,4,5,5a,6,8,10,10a,10b,11,12,12a-hexadecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-ol
InChIKey: MHDDZDPNIDVLNK-ZGIWMXSJSA-N
SMILES: C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])CC4=NN(S(C)(=O)=O)C=C4C2)([H])[C@@]5([H])[C@](CC3)([C@@](O)(CC5)C#C)C
Biological Activity: Zanoterone is an orally active antagonist of the androgen receptor (AR) with a Ki of 2.2 μM. Zanoterone blocks the binding of androgens such as testosterone and dihydrotestosterone (DHT), inhibiting the androgen signaling pathway, thereby reducing androgen-dependent prostate hyperplasia and prostate cancer growth[1].
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Zanoterone | Zanoterone is an orally active antagonist of the androgen receptor (AR) with a Ki of 2.2 μM. Zanoterone blocks the binding of androgens such as testosterone and dihydrotestosterone (DHT), inhibiting the androgen signaling pathway, thereby reducing androgen-dependent prostate hyperplasia and prostate cancer growth. | |||||||||||||||||||||
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