107008-28-6
107008-28-6
Chemical Structure
RU 24969 succinate
- CAS No.: 107008-28-6
- Formula:C18H22N2O5
- Molecular Weight:346.38
IUPAC Name: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole succinate
InChIKey: AFNQSRYIQUAMNM-UHFFFAOYSA-N
SMILES: O=C(O)CCC(O)=O.COC1=CC=C2C(C(C3=CCNCC3)=CN2)=C1
Biological Activity: RU 24969 succinate is a 5-HT receptor agonist with Ki values of 0.38 and 2.5 nM for 5-HT1B and 5-HT1A, respectively. RU 24969 decreases fluid consumption and increases forward locomotion. RU 24969 succinate can be used for the research of neurological disease[1][2][3][4].
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RU 24969 succinate | 99.58% | RU 24969 succinate is a 5-HT receptor agonist with Ki values of 0.38 and 2.5 nM for 5-HT1B and 5-HT1A, respectively. RU 24969 decreases fluid consumption and increases forward locomotion. RU 24969 succinate can be used for the research of neurological disease. | ||||||||||||||||||||
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References
- [1]. Middlemiss DN. The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor. J Pharm Pharmacol. 1985 Jun;37(6):434-7. [Content Brief]
- [2]. Parsons LH, et al. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse. 1999 May;32(2):132-5. [Content Brief]
- [3]. Peroutka SJ. Pharmacological differentiation and characterization of 5-HT1A, 5-HT1B, and 5-HT1C binding sites in rat frontal cortex. J Neurochem. 1986 Aug;47(2):529-40. [Content Brief]
- [4]. Aronsen D, et al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep;124:1-4. [Content Brief]
