107019-95-4
107019-95-4
Chemical Structure
Hymenidin
- CAS No.: 107019-95-4
- Formula:C11H12BrN5O
- Molecular Weight:310.15
IUPAC Name: (E)-N-(3-(2-amino-1H-imidazol-5-yl)allyl)-4-bromo-1H-pyrrole-2-carboxamide
InChIKey: KHJREOQCERRAME-OWOJBTEDSA-N
SMILES: O=C(NC/C=C/C1=CN=C(N1)N)C2=CC(Br)=CN2
Biological Activity: Hymenidin is a natural antagonist of serotonergic receptor and inhibitor of voltage-gated potassium channels. Hymenidin also induces cancer cell apoptosis[1][2][3].
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Hymenidin | Hymenidin is a natural antagonist of serotonergic receptor and inhibitor of voltage-gated potassium channels. Hymenidin also induces cancer cell apoptosis. | |||||||||||||||||||||
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References
- [1]. Kobayashi J, et al. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp. Experientia. 1986 Oct 15;42(10):1176-7. [Content Brief]
- [2]. Zidar N, et al. Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem. 2017 Oct 20;139:232-241. [Content Brief]
- [3]. Tihomir Tomašič, et al. Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells. MedChemComm. 2015, 6(1): 105-110.
