1071000-98-0
1071000-98-0
Chemical Structure
FKGK11
- CAS No.: 1071000-98-0
- Formula:C13H13F5O
- Molecular Weight:280.23
IUPAC Name: 1,1,1,2,2-pentafluoro-7-phenylheptan-3-one
InChIKey: ROPVXAWEVYWEQY-UHFFFAOYSA-N
SMILES: O=C(C(F)(C(F)(F)F)F)CCCCC1=CC=CC=C1
Biological Activity: FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis[1][2].
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FKGK11 | FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis. | |||||||||||||||||||||
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References
- [1]. Kokotos G, et al. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. [Content Brief]
- [2]. Yan Xu, et al. Abstract 3525: Targeting Group VIA phospholipase A2 using small molecules for ovarian cancer treatment. Cancer Res (2011) 71 (8_Supplement): 3525.
