1072931-48-6
Chemical Structure
Cochliodone A
- CAS No.: 1072931-48-6
- Formula:C34H38O12
- Molecular Weight:638.66
IUPAC Name: (3S,3''S,6'R,6'''R,7R,7''S)-6',6''',7,7''-tetramethyl-6,6'',8,8''-tetraoxo-5,5''-bispiro[isochromene-3,2'-pyran]-7,7''-diyl diacetate
InChIKey: XDRDZGUQBNNXLG-SQNVWISRSA-N
SMILES: O=C(C1=CO[C@@]2(CCC[C@@H](C)O2)CC1=C3C(C([C@@](OC(C)=O)(C)C4=O)=O)=C5C4=CO[C@]6(O[C@H](C)CCC6)C5)[C@](C)(OC(C)=O)C3=O
Biological Activity: Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2)[1].
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Cochliodone A | Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2). | |||||||||||||||||||||
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