107332-47-8
Chemical Structure
SQ-30741
- CAS No.: 107332-47-8
- Formula:C23H38N2O5
- Molecular Weight:422.56
IUPAC Name: (Z)-7-((1S,2R,3R,4R)-3-((2-heptanamidoacetamido)methyl)-7-oxabicyclo[2.2.1]heptan-2-yl)hept-5-enoic acid
InChIKey: OPZODFCEYJMBAM-OXVBEWKXSA-N
SMILES: O=C(O)CCC/C=C\C[C@H]1[C@](O2)([H])CC[C@]2([H])[C@H]1CNC(CNC(CCCCCC)=O)=O
Biological Activity: SQ-30741 is a thromboxane A2 receptor antagonist. SQ-30741 reduces vasoconstriction in a feline pulmonary vascular bed model. SQ-30741 increases relaxation of aortic endothelium and vascular smooth muscle in adult rats in a spontaneously hypertensive rat model. SQ-30741 can be used in research on cardiovascular diseases such as hypertension[1][2].
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SQ-30741 | SQ-30741 is a thromboxane A2 receptor antagonist. SQ-30741 reduces vasoconstriction in a feline pulmonary vascular bed model. SQ-30741 increases relaxation of aortic endothelium and vascular smooth muscle in adult rats in a spontaneously hypertensive rat model. SQ-30741 can be used in research on cardiovascular diseases such as hypertension. | |||||||||||||||||||||
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References
- [1]. McMahon TJ, et al. Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed. J Appl Physiol (1985). 1991 Nov;71(5):2012-8. [Content Brief]
- [2]. Küng CF, et al. Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Hypertension. 1995 Feb;25(2):194-200. [Content Brief]
