107430-03-5
Chemical Structure
Moflomycin
Synonym(s): F 860191
- CAS No.: 107430-03-5
- Formula:C25H25IO10
- Molecular Weight:612.36
IUPAC Name: (7S,9S)-7-(((2R,3R,4R,5R,6S)-4,5-dihydroxy-3-iodo-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,9,11-trihydroxy-9-(hydroxymethyl)-7,8,9,10-tetrahydrotetracene-5,12-dione
InChIKey: IJWZCUDUUDYUBR-IWGZIANCSA-N
SMILES: O=C(C1=C2C(O)=C3C[C@](CO)(O)C[C@H](O[C@H]4[C@H](I)[C@@H]([C@H]([C@H](C)O4)O)O)C3=C1O)C5=CC=CC=C5C2=O
Biological Activity: Moflomycin (F 860191) is a compound with strong anti-leukemic activity and low mutagenicity. Moflomycin has an antiproliferative effect on the leukemic cell line HL60 in vitro (IC50=2.9 nM)[1]. Moflomycin enhances topoisomerase II-induced DNA breaks and free radical production[2].
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Moflomycin | Moflomycin (F 860191) is a compound with strong anti-leukemic activity and low mutagenicity. Moflomycin has an antiproliferative effect on the leukemic cell line HL60 in vitro (IC50=2.9 nM). Moflomycin enhances topoisomerase II-induced DNA breaks and free radical production. | |||||||||||||||||||||
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References
- [1]. Andrivon W, et al. A new anthracycline with potent antileukemic activity exhibits reduced mutagenicity[J]. Mutation Research/Genetic Toxicology, 1995, 344(3-4): 135-140. [Content Brief]
- [2]. Andrivon W, et al. Enhanced topoisomerase II-induced DNA breaks and free radical production by a new anthracycline with potent antileukemic activity. Leuk Res. 1996 Feb;20(2):119-26. [Content Brief]
