1076235-04-5
1076235-04-5
Chemical Structure
Felezonexor
Synonym(s): CBS9106; SL-801
- CAS No.: 1076235-04-5
- Formula:C18H21ClF3N3O3
- Molecular Weight:419.83
IUPAC Name: 1-((6-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)-3-((3,3-dimethylbutoxy)methyl)-4-methyl-1H-pyrrole-2,5-dione
InChIKey: CMASLSTVVOYJQY-UHFFFAOYSA-N
SMILES: O=C(C(COCCC(C)(C)C)=C1C)N(NC2=NC(Cl)=C(C(F)(F)F)C=C2)C1=O
Biological Activity: CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities. CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells[1].
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Felezonexor | 99.79% | CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities. CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells. | ||||||||||||||||||||
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