107761-24-0
107761-24-0
Chemical Structure
ST638
- CAS No.: 107761-24-0
- Formula:C19H18N2O3S
- Molecular Weight:354.42
IUPAC Name: (E)-2-cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)phenyl)acrylamide
InChIKey: YKLMGKWXBLSKPK-RIYZIHGNSA-N
SMILES: O=C(N)/C(C#N)=C/C1=CC(CSC2=CC=CC=C2)=C(O)C(OCC)=C1
Biological Activity: ST638 is a potent tyrosine kinase inhibitor (IC50=370 nM). ST638 also targets the CSF-1 receptor and inhibits PGE2 production[1][2].
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ST638 | ST638 is a potent tyrosine kinase inhibitor (IC50=370 nM). ST638 also targets the CSF-1 receptor and inhibits PGE2 production. | |||||||||||||||||||||
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References
- [1]. Puri J, et al. Selective inhibition of PGE2 production in cells transfected with c-fms encoded CSF-1 receptor genes by the tyrosine kinase inhibitor, ST638. Agents Actions. 1991 Jul;33(3-4):314-7. [Content Brief]
- [2]. Fuortes M, et al. Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor. J Cell Biol. 1993 Feb;120(3):777-84. [Content Brief]
