1077626-52-8
1077626-52-8
Chemical Structure
CAY10589
- CAS No.: 1077626-52-8
- Formula:C25H28ClN3O2S
- Molecular Weight:470.03
IUPAC Name: 2-((4-(([1,1'-biphenyl]-4-ylmethyl)amino)-6-chloropyrimidin-2-yl)thio)octanoic acid
InChIKey: FQMPYBCEABTPIK-UHFFFAOYSA-N
SMILES: O=C(C(CCCCCC)SC1=NC(Cl)=CC(NCC2=CC=C(C3=CC=CC=C3)C=C2)=N1)O
Biological Activity: CAY10589 is an inhibitor of mPGES-1, an enzyme induced during inflammatory responses. CAY10589 has no significant effect on the differentiation of BM myeloid precursor cells into M2-like TAMs[1][2].
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CAY10589 | CAY10589 is an inhibitor of mPGES-1, an enzyme induced during inflammatory responses. CAY10589 has no significant effect on the differentiation of BM myeloid precursor cells into M2-like TAMs. | |||||||||||||||||||||
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References
- [1]. Wiegard A, et al. Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1. Eur J Med Chem. 2012 Feb;48:153-63. [Content Brief]
- [2]. Li L, et al. Targeting the lipid metabolic reprogramming of tumor-associated macrophages: A novel insight into cancer immunotherapy. Cell Oncol (Dordr). 2023 Sep 30. [Content Brief]
