1078-61-1
1078-61-1
Chemical Structure
Dihydrocaffeic acid
Synonym(s): 3,4-Dihydroxy-benzenepropanoic acid
- CAS No.: 1078-61-1
- Formula:C9H10O4
- Molecular Weight:182.17
IUPAC Name: 3-(3,4-dihydroxyphenyl)propanoic acid
InChIKey: DZAUWHJDUNRCTF-UHFFFAOYSA-N
SMILES: O=C(O)CCC1=CC=C(O)C(O)=C1
Biological Activity: Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dihydrocaffeic acid | 99.86% | Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities. | ||||||||||||||||||||
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Dihydrocaffeic acid (Standard) | 99.88% | Dihydrocaffeic acid (Standard) (3,4-Dihydroxy-benzenepropanoic acid (Standard)) is the analytical standard of Dihydrocaffeic acid (HY-N2406). This product is intended for research and analytical applications. Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities. | ||||||||||||||||||||
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Dihydrocaffeic acid-13C | Dihydrocaffeic acid-13C (3,4-Dihydroxy-benzenepropanoic acid-13C) is the 13C-labeled Dihydrocaffeic acid (HY-N2406). Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities. | |||||||||||||||||||||
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References
- [1]. Oliveira MM, et al. Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway. Oxid Med Cell Longev. 2019 Jan 17;2019:2419096. [Content Brief]
- [2]. Botta G, et al. Carbon nanotubes supported tyrosinase in the synthesis of lipophilic hydroxytyrosol and dihydrocaffeoyl catechols with antiviral activity against DNA and RNA viruses. Bioorg Med Chem. 2015 Sep 1;23(17):5345-51. [Content Brief]
- [3]. Vázquez R, et al. Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. Bioorg Med Chem. 2012 Sep 15;20(18):5537-49. [Content Brief]
- [4]. Huang J, et al. Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells. J Nutr Biochem. 2004 Dec;15(12):722-9. [Content Brief]
- [5]. Poquet L, et al. Effect of dihydrocaffeic acid on UV irradiation of human keratinocyte HaCaT cells. Arch Biochem Biophys. 2008 Aug 15;476(2):196-204. [Content Brief]
- [6]. Lu R, et al. Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways. Bone Joint Res. 2023 Apr 6;12(4):259-273. [Content Brief]
- [7]. Baeza G, et al. The colonic metabolites dihydrocaffeic acid and dihydroferulic acid are more effective inhibitors of in vitro platelet activation than their phenolic precursors. Food Funct. 2017 Mar 22;8(3):1333-1342. [Content Brief]
- [8]. Lee K, et al. Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model. Molecules. 2015 Jun 30;20(7):11930-40. [Content Brief]
