107813-86-5
107813-86-5
Chemical Structure
LTD4 antagonist 2
- CAS No.: 107813-86-5
- Formula:C17H13NO3
- Molecular Weight:279.29
InChIKey: IJTITQLHFRUEQF-UHFFFAOYSA-N
SMILES: O=C(C1=CC(OCC2=NC3=C(C=C2)C=CC=C3)=CC=C1)O
Biological Activity: LTD4 antagonist 2 (compound 6) is a leukotriene D4 (LTD4) antagonist with an IC50 of 2.8 μM against cysteinyl leukotriene 1 receptor (CysLT1R). LTD4 antagonist 2 is also a G protein-coupled bile acid receptor 1 (GPBAR1) agonist and can be utilized in research related to colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1][2].
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LTD4 antagonist 2 | LTD4 antagonist 2 (compound 6) is a leukotriene D4 (LTD4) antagonist with an IC50 of 2.8 μM against cysteinyl leukotriene 1 receptor (CysLT1R). LTD4 antagonist 2 is also a G protein-coupled bile acid receptor 1 (GPBAR1) agonist and can be utilized in research related to colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases. | |||||||||||||||||||||
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References
- [1]. Fiorillo B, et al. Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64(22):16512-16529. [Content Brief]
- [2]. Musser JH, et al. N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure. J Med Chem. 1990 Jan;33(1):240-5. [Content Brief]
