1081317-31-8
1081317-31-8
Chemical Structure
DA-0218
- CAS No.: 1081317-31-8
- Formula:C36H37N3O2
- Molecular Weight:543.70
InChIKey: IMLBZPJYUUDNNW-UHFFFAOYSA-N
SMILES: O=C(NCCN1CCCC1)CC(C2=CC=CC(OC3=CC=CC=C3)=C2)C4=CN(CC5=CC=CC=C5)C6=C4C=CC=C6
Biological Activity: DA-0218 is a Nav1.7 inhibitor. DA-0218 exerts state-dependent inhibitory effects. DA-0218 alleviates formalin-induced inflammatory pain behavior and Paclitaxel-induced mechanical hyperalgesia in mice. DA-0218 inhibits Histamine-induced acute pruritus and lymphoma-induced chronic pruritus in mice. DA-0218 can be used in research related to inflammatory pain, neuropathic pain, acute pruritus and chronic pruritus[1][2].
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DA-0218 | DA-0218 is a Nav1.7 inhibitor. DA-0218 exerts state-dependent inhibitory effects. DA-0218 alleviates formalin-induced inflammatory pain behavior and Paclitaxel-induced mechanical hyperalgesia in mice. DA-0218 inhibits Histamine-induced acute pruritus and lymphoma-induced chronic pruritus in mice. DA-0218 can be used in research related to inflammatory pain, neuropathic pain, acute pruritus and chronic pruritus. | |||||||||||||||||||||
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References
- [1]. Andrey BORTSOV, et al. Small molecule inhibitors of voltage-gated sodium channel 1.7 and methods of using same. WO2021119157A1. 2022-06-11.
- [2]. Chandra S, et al. Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. Anesthesiology. 2020;133(3):611-627. [Content Brief]
