108750-13-6
Chemical Structure
Calcein sodium salt
- CAS No.: 108750-13-6
- Formula:C30H26N2O13
- Molecular Weight:622.53
IUPAC Name: tert-butyl (3-oxopyrazolidin-4-yl)carbamate
SMILES: O=C(CN(CC1=C(O)C=C(OC2=CC(O)=C(CN(CC(O)=O)CC(O)=O)C=C2C34OC(C5=C4C=CC=C5)=O)C3=C1)CC(O)=O)O.[xNa]
Biological Activity: Calcein sodium is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium. Calcein cannot directly cross the intact cell membrane of a living cell, unlike Calcein-AM (HY-D0041) which is cell-permeable. Calcein can also be used as a model drug for evaluating efficiency and bioavailability of drug delivery systems[1][2].
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Calcein sodium salt | Calcein sodium is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium. Calcein cannot directly cross the intact cell membrane of a living cell, unlike Calcein-AM (HY-D0041) which is cell-permeable. Calcein can also be used as a model drug for evaluating efficiency and bioavailability of drug delivery systems. | |||||||||||||||||||||
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References
- [1]. Marques-Santos LF, et al. ABCB1 and ABCC1-like transporters in immune system cells from sea urchins Echinometra lucunter and Echinus esculentus and oysters Crassostrea gasar and Crassostrea gigas. Fish Shellfish Immunol. 2017 Sep 5;70:195-203. [Content Brief]
- [2]. Maherani B, et al., Calcein release behavior from liposomal bilayer; influence of physicochemical/mechanical/structural properties of lipids. Biochimie. 2013 Nov;95(11):2018-33. [Content Brief]
