1091682-50-6
Chemical Structure
IDP-73152
- CAS No.: 1091682-50-6
- Formula:C28H41F3N4O4
- Molecular Weight:554.66
IUPAC Name: (R)-3-cyclopentyl-N-((S)-3,3-dimethyl-1-oxo-1-(4-((2,4,5-trifluorobenzyl)amino)piperidin-1-yl)butan-2-yl)-2-((N-hydroxyformamido)methyl)propanamide
InChIKey: SCVZUKPARGIVBE-CJFMBICVSA-N
SMILES: [C@@H](C(N[C@H](C(=O)N1CCC(NCC2=C(F)C=C(F)C(F)=C2)CC1)C(C)(C)C)=O)(CC3CCCC3)CN(C=O)O
Biological Activity: IDP-73152 is an orally active bacterial Peptide deformylase inhibitor and Antibiotic. IDP-73152 exhibits activity against Gram-positive bacteria. IDP-73152 can be used in the research of infections caused by Streptococcus pneumoniae, Enterococcus faecium and Staphylococcus aureus[1][2][3].
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IDP-73152 | IDP-73152 is an orally active bacterial Peptide deformylase inhibitor and Antibiotic. IDP-73152 exhibits activity against Gram-positive bacteria. IDP-73152 can be used in the research of infections caused by Streptococcus pneumoniae, Enterococcus faecium and Staphylococcus aureus. | |||||||||||||||||||||
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References
- [1]. Lee M, et al. Quantification of IDP-73152, a novel antibiotic, in plasma from mice, rats and humans using an ultra-high performance liquid chromatography/tandem mass spectrometry method for use in pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2017 Oct 25;145:364-371.
- [2]. 이명재. Physiologically-based pharmacokinetic modeling of a novel antibacterial drug (IDP-73152) for prediction of its pharmacokinetics in humans[D]. 서울대학교 대학원, 2022.
- [3]. Lee M, et al. Prediction of Pharmacokinetics of IDP-73152 in Humans Using Physiologically-Based Pharmacokinetics. Pharmaceutics. 2022 May 28;14(6):1157.
