109229-57-4
Chemical Structure
Englitazone sodium
- CAS No.: 109229-57-4
- Formula:C20H19NNaO3S
- Molecular Weight:376.42
IUPAC Name: sodium 5-((2-benzylchroman-6-yl)methyl)-2,4-dioxothiazolidin-3-ide
InChIKey: ZPXDFTWEKFBLSH-UHFFFAOYSA-N
SMILES: O=C1SC(CC2=CC=C3OC(CCC3=C2)CC4=CC=CC=C4)C(N1)=O.[Na]
Biological Activity: Englitazone sodium is a thiazolidinedione compound. Englitazone sodium selectively activates PPARγ1 and PPARγ2. Englitazone sodium improves insulin sensitivity, induces adipogenesis in preadipocytes and mesenchymal stem cells, and inhibits the channel currents of Kir6.2-SUR1 and Kir6.2D26. Englitazone sodium is applicable to research related to non-insulin-dependent diabetes mellitus[1][2].
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Englitazone sodium | Englitazone sodium is a thiazolidinedione compound. Englitazone sodium selectively activates PPARγ1 and PPARγ2. Englitazone sodium improves insulin sensitivity, induces adipogenesis in preadipocytes and mesenchymal stem cells, and inhibits the channel currents of Kir6.2-SUR1 and Kir6.2D26. Englitazone sodium is applicable to research related to non-insulin-dependent diabetes mellitus. | |||||||||||||||||||||
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References
- [1]. Lehmann JM, et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). The Journal of biological chemistry. 1995 Jun 02;270(22):12953-6. [Content Brief]
- [2]. McKay NG, et al. Sensitivity of Kir6.2-SUR1 currents, in the absence and presence of sodium azide, to the K(ATP) channel inhibitors, ciclazindol and englitazone. British journal of pharmacology. 2000 Jun;130(4):857-66.
