1092380-14-7
Chemical Structure
20-5,14-HEDGE
- CAS No.: 1092380-14-7
- Formula:C22H39NO4
- Molecular Weight:381.55
IUPAC Name: ((5Z,14Z)-20-hydroxyicosa-5,14-dienoyl)glycine
InChIKey: YMORNHKJBUFZDD-GEHMVYPESA-N
SMILES: OC(CNC(CCC/C=C\CCCCCCC/C=C\CCCCCO)=O)=O
Biological Activity: 20-5,14-HEDGE is a 20-HETE analog. 20-5,14-HEDGE induces cell death in organotypic hippocampal slice cultures (OHSCs). 20-5,14-HEDGE enhances ROS production and reduces hypoxia-reoxygenation (HR)-induced apoptosis in ex vivo rat lung slices. 20-5,14-HEDGE protects against lung ischemic reperfusion injury in rats. 20-5,14-HEDGE can be used for the study of pulmonary vascular signaling and lung injury-related research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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20-5,14-HEDGE | 99.28% | 20-5,14-HEDGE is a 20-HETE analog. 20-5,14-HEDGE induces cell death in organotypic hippocampal slice cultures (OHSCs). 20-5,14-HEDGE enhances ROS production and reduces hypoxia-reoxygenation (HR)-induced apoptosis in ex vivo rat lung slices. 20-5,14-HEDGE protects against lung ischemic reperfusion injury in rats. 20-5,14-HEDGE can be used for the study of pulmonary vascular signaling and lung injury-related research. | ||||||||||||||||||||
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References
- [1]. Han R, et al. 20-HETE Participates in Intracerebral Hemorrhage-Induced Acute Injury by Promoting Cell Ferroptosis. Front Neurol. 2021 Nov 12;12:763419. [Content Brief]
- [2]. Ali I, et al. Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. Ann Thorac Surg. 2012 Jan;93(1):282-8. [Content Brief]
- [3]. Jacobs ER, et al. Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices. Exp Cell Res. 2012 Oct 1;318(16):2143-52. [Content Brief]
