1092460-91-7
1092460-91-7
Chemical Structure
RAGE antagonist peptide
- CAS No.: 1092460-91-7
- Formula:C57H101N13O17S
- Molecular Weight:1272.55
InChIKey: VNWKTOKETHGBQD-UHFFFAOYSA-N
SMILES: CC(C)C[C@@H](C(N)=O)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H](CCSC)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities[1][2].
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RAGE antagonist peptide | 98.16% | RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities. | ||||||||||||||||||||
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References
- [1]. Thiruvengadam Arumugam, et al. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012 Aug 15;18(16):4356-64. [Content Brief]
- [2]. Lihong Yao, et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016 Sep;173(17):2600-13. [Content Brief]
