1092539-44-0
1092539-44-0
Chemical Structure
(Rac)-SAR131675
- CAS No.: 1092539-44-0
- Formula:C18H22N4O4
- Molecular Weight:358.39
IUPAC Name: 2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
InChIKey: PFMPOBVAYMTUOX-UHFFFAOYSA-N
SMILES: O=C(C1=C(N)N(CC)C2=C(C=CC(C#CC(C)(O)COC)=N2)C1=O)NC
Biological Activity: (Rac)-SAR131675 is the racemate of SAR131675. SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM[1][2].
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(Rac)-SAR131675 | (Rac)-SAR131675 is the racemate of SAR131675. SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM. | |||||||||||||||||||||
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References
- [1]. Mitroshina EV, et al. Neuroprotective Effect of Kinase Inhibition in Ischemic Factor Modeling In Vitro. Int J Mol Sci. 2021;22(4):1885. [Content Brief]
- [2]. Alam A, et al. SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. Mol Cancer Ther. 2012 Aug;11(8):1637-49. [Content Brief]
