1093130-72-3
Chemical Structure
Veledimex
Synonym(s): INXN-1001; RG-115932
- CAS No.: 1093130-72-3
- Formula:C27H38N2O3
- Molecular Weight:438.60
IUPAC Name: (R)-N'-(3,5-dimethylbenzoyl)-N'-(2,2-dimethylhexan-3-yl)-2-ethyl-3-methoxybenzohydrazide
InChIKey: LZWZPGLVHLSWQX-XMMPIXPASA-N
SMILES: O=C(NN(C(C1=CC(C)=CC(C)=C1)=O)[C@@H](C(C)(C)C)CCC)C2=CC=CC(OC)=C2CC
Biological Activity: Veledimex (INXN-1001), a synthetic analog of the insect molting hormone ecdysone, is an orally active activator ligand for a proprietary gene therapy promoter system. Veledimex can be used to activate certain genes using the ecdysone receptor (EcR)-based inducible gene regulation system, the RheoSwitch Therapeutic System (RTS). Veledimex can cross blood-brain barrier (BBB) in both orthotopic GL-261 mice and cynomolgus monkeys[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Veledimex | 98.77% | Veledimex (INXN-1001), a synthetic analog of the insect molting hormone ecdysone, is an orally active activator ligand for a proprietary gene therapy promoter system. Veledimex can be used to activate certain genes using the ecdysone receptor (EcR)-based inducible gene regulation system, the RheoSwitch Therapeutic System (RTS). Veledimex can cross blood-brain barrier (BBB) in both orthotopic GL-261 mice and cynomolgus monkeys. | ||||||||||||||||||||
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References
- [1]. Barrett JA, et al. Regulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System® (RTS®) gene switch as gene therapy for the treatment of glioma. Cancer Gene Ther. 2018;25(5-6):106-116. [Content Brief]
- [2]. Chiocca EA, et al. Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial. Sci Transl Med. 2019;11(505):eaaw5680. [Content Brief]
