1093793-05-5
1093793-05-5
Chemical Structure
PV-1019
Synonym(s): NSC 744039
- CAS No.: 1093793-05-5
- Formula:C18H17N7O3
- Molecular Weight:379.37
IUPAC Name: (E)-N-(4-(1-(2-carbamimidoylhydrazono)ethyl)phenyl)-7-nitro-1H-indole-2-carboxamide
InChIKey: ZKHRFTLMLVMQMS-AUEPDCJTSA-N
SMILES: O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)NC3=CC=C(/C(C)=N/NC(N)=N)C=C3
Biological Activity: PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768)-induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis[1].
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PV-1019 | 98.66% | PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768)-induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis. | ||||||||||||||||||||
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References
- [1]. Jobson AG, et, al. Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. J Pharmacol Exp Ther. 2009 Dec;331(3):816-26. [Content Brief]
