1093793-10-2
1093793-10-2
Chemical Structure
PV1115
- CAS No.: 1093793-10-2
- Formula:C20H19N7O3
- Molecular Weight:405.41
IUPAC Name: (E)-N-(4-(1-(2-(4,5-dihydro-1H-imidazol-2-yl)hydrazono)ethyl)phenyl)-7-nitro-1H-indole-2-carboxamide
InChIKey: JNXXELFPDAKQCG-BRJLIKDPSA-N
SMILES: O=C(NC1=CC=C(C=C1)/C(C)=N/NC2=NCCN2)C3=CC4=C(C([N+]([O-])=O)=CC=C4)N3
Biological Activity: PV1115 is a potent and highly selective Chk2 inhibitor with an IC50 of 0.14 nM, 66000 nM, >100000 nM for Chk2, Chk1 and RSK2, respectively. PV1115 is situated within the ATP-binding pocket of Chk2[1].
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PV1115 | PV1115 is a potent and highly selective Chk2 inhibitor with an IC50 of 0.14 nM, 66000 nM, >100000 nM for Chk2, Chk1 and RSK2, respectively. PV1115 is situated within the ATP-binding pocket of Chk2. | |||||||||||||||||||||
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