1094848-99-3
1094848-99-3
Chemical Structure
HYNIC-3P-RGD2
- CAS No.: 1094848-99-3
- Formula:C98H155N25O32
- Molecular Weight:2195.43
InChIKey: CMZZCMDZLGWDII-QIGAWXTGSA-N
SMILES: O=C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N1)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CCCCNC(CCOCCOCCOCCOCCNC([C@@H](NC(CCOCCOCCOCCOCCNC(C(C=C/2)=CNC2=N/N)=O)=O)CCC(NCCOCCOCCOCCOCCC(NCCCC[C@@H]3NC([C@H](NC([C@@H](NC(CNC([C@@H](NC3=O)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)[C@H]1CC5=CC=CC=C5
Biological Activity: HYNIC-3P-RGD2 is a dimeric cyclic RGD peptide with high binding affinity for integrin αvβ3 (IC50 = 33 nM). HYNIC-3P-RGD2 acts as a precursor molecule for radiotracers and is used to detect tumor angiogenesis[1][2].
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HYNIC-3P-RGD2 | HYNIC-3P-RGD2 is a dimeric cyclic RGD peptide with high binding affinity for integrin αvβ3 (IC50 = 33 nM). HYNIC-3P-RGD2 acts as a precursor molecule for radiotracers and is used to detect tumor angiogenesis. | |||||||||||||||||||||
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References
- [1]. Xu D, et al. Iminodiacetic acid as bifunctional linker for dimerization of cyclic RGD peptides. Nucl Med Biol. 2017 May;48:1-8. [Content Brief]
- [2]. Jia B, et al. Blood clearance kinetics, biodistribution, and radiation dosimetry of a kit-formulated integrin αvβ3-selective radiotracer 99mTc-3PRGD 2 in non-human primates. Mol Imaging Biol. 2011 Aug;13(4):730-6. [Content Brief]
