109543-76-2
109543-76-2
Chemical Structure
Romazarit
Synonym(s): RO 31-3948
- CAS No.: 109543-76-2
- Formula:C15H16ClNO4
- Molecular Weight:309.74
IUPAC Name: 2-((2-(4-chlorophenyl)-4-methyloxazol-5-yl)methoxy)-2-methylpropanoic acid
InChIKey: LNXXSBRGLBOASF-UHFFFAOYSA-N
SMILES: CC(C)(OCC1=C(C)N=C(C2=CC=C(Cl)C=C2)O1)C(O)=O
Biological Activity: Romazarit (RO 31-3948) is an anti-inflammatory agent with antirheumatic effect. Romazarit exhibits PPARα agonist activity. Romazarit (30 mg/kg) inhibits the development of hindpaw inflammation in an adjuvant arthritis model[1][2][3].
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Romazarit | Romazarit (RO 31-3948) is an anti-inflammatory agent with antirheumatic effect. Romazarit exhibits PPARα agonist activity. Romazarit (30 mg/kg) inhibits the development of hindpaw inflammation in an adjuvant arthritis model. | |||||||||||||||||||||
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References
- [1]. Bloxham DP, et al. Biologic properties of romazarit (Ro 31-3948), a potential disease-modifying antirheumatic drug. J Pharmacol Exp Ther. 1990 Mar;252(3):1331-40. [Content Brief]
- [2]. Pillai AD, et al. Tetra substituted thiophenes as anti-inflammatory agents: exploitation of analogue-based drug design. Bioorg Med Chem. 2005 Dec 15;13(24):6685-92. [Content Brief]
- [3]. Clary Clish, et al. Romazarit for treating metabolic diseases. WO2010014771A1.
