110072-15-6
110072-15-6
Chemical Structure
Tosagestin
Synonym(s): Org 30659
- CAS No.: 110072-15-6
- Formula:C21H24O2
- Molecular Weight:308.41
IUPAC Name: (8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-11-methylene-1,2,6,7,8,9,10,11,12,13,14,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
InChIKey: YJSTYQGZKJHXLN-OLGWUGKESA-N
SMILES: C[C@]1(C2)[C@](C=C[C@@]1(O)C#C)([H])[C@@]3([H])[C@]([C@]4([H])C(CC3)=CC(CC4)=O)([H])C2=C
Biological Activity: Tosagestin(Org 30659) is a 19-nortestosterone–derived progestagen. Tosagestinsuppresses ovarian function to a level sufficient to inhibit ovulation. Tosagestininhibits cell growth in T47D-S cells[1][2].
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Tosagestin | Tosagestin(Org 30659) is a 19-nortestosterone–derived progestagen. Tosagestinsuppresses ovarian function to a level sufficient to inhibit ovulation. Tosagestininhibits cell growth in T47D-S cells. | |||||||||||||||||||||
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References
- [1]. Schoonen WG, et al. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines. J Steroid Biochem Mol Biol. 1995;55(3-4):439-444. 、 [Content Brief]
- [2]. Obruca A, et al. Ovarian function during and after treatment with the new progestagen Org 30659. Fertil Steril. 2001;76(1):108-115. [Content Brief]
