110347-85-8
110347-85-8
Chemical Structure
Selfotel
Synonym(s): CGS 19755
- CAS No.: 110347-85-8
- Formula:C7H14NO5P
- Molecular Weight:223.16
IUPAC Name: (2R,4S)-4-(phosphonomethyl)piperidine-2-carboxylic acid
InChIKey: LPMRCCNDNGONCD-NTSWFWBYSA-N
SMILES: O=C([C@@H]1NCC[C@H](CP(O)(O)=O)C1)O
Biological Activity: Selfotel (CGS 19755) is a selective and competitive antagonist at N-methyl-D-aspartate (NMDA)-preferring receptor. CGS 19755 inhibits the binding of [3H]-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to NMDA-type receptors with an IC50 of 50 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Selfotel | 99.88% | Selfotel (CGS 19755) is a selective and competitive antagonist at N-methyl-D-aspartate (NMDA)-preferring receptor. CGS 19755 inhibits the binding of [3H]-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to NMDA-type receptors with an IC50 of 50 nM. | ||||||||||||||||||||
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PMPA (NMDA antagonist) | PMPA (NMDA antagonist) is an NMDA receptor antagonist with Ki values of 0.84, 2.74, 3.53 and 4.16 μM for NR2A, NR2B, NR2C and NR2D, respectively. | |||||||||||||||||||||
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LY 221501 | LY 221501 is an active compound. | |||||||||||||||||||||
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cis-Piperidine-2,3-dicarboxylic acid | 95.0% | Cis-piperidine-2,3-dicarboxylic acid is a non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Cis-piperidine-2,3-dicarboxylic acid can be used in blocking general excitatory synaptic transmissions. | ||||||||||||||||||||
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4-Piperidineacetic acid hydrochloride | 4-Piperidineacetic acid hydrochloride is a PROTAC linker that can be used in the synthesis of PROTACs. | |||||||||||||||||||||
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L-Pipecolic acid | 99.89% | L-Pipecolic acid (H-HoPro-OH) is an oral active metabolite of Lysine and can accumulate in the bodily fluids of infants with autosomal inherited diseases, such as Zellweger syndrome and neonatal adrenal insufficiency. L-Pipecolic acid can promote muscle cell health and growth by enhancing protein synthesis, and plays a role in promoting gut health. L-Pipecolic acid holds promise for research in the fields of metabolic disorders, muscle growth disorders, and intestinal diseases. | ||||||||||||||||||||
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D-Pipecolinic acid (Standard) | 98.91% | D-Pipecolinic acid is a normal human metabolite found in human biofluids. | ||||||||||||||||||||
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L-Proline | 98.0% | L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. | ||||||||||||||||||||
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L-Proline-13C5 | 99.93% | L-Proline-13C5 is the 13C-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. | ||||||||||||||||||||
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L-Proline-13C5,15N | 99.93% | L-Proline-13C5,1-15N is the 13C- and 15N-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins. | ||||||||||||||||||||
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Pipecolic acid (Standard) | 98.97% | Pipecolic acid (Standard) is the analytical standard of Pipecolic acid. This product is intended for research and analytical applications. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy. | ||||||||||||||||||||
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References
- [1]. D A Bennett, et al. Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors. J Pharmacol Exp Ther. 1989 Aug;250(2):454-60. [Content Brief]
- [2]. J Lehmann, et al. CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. J Pharmacol Exp Ther. 1988 Jul;246(1):65-75. [Content Brief]
