110448-31-2
110448-31-2
Chemical Structure
ML-9 Free Base
- CAS No.: 110448-31-2
- Formula:C15H17ClN2O2S
- Molecular Weight:324.83
IUPAC Name: 1-((5-chloronaphthalen-1-yl)sulfonyl)-1,4-diazepane
InChIKey: OZSMSRIUUDGTEP-UHFFFAOYSA-N
SMILES: O=S(N1CCNCCC1)(C2=C3C=CC=C(C3=CC=C2)Cl)=O
Biological Activity: ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3].
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ML-9 Free Base | ML-9 (Free Base) is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 (Free Base) inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively. ML-9 (Free Base) induces autophagy by stimulating autophagosome formation and inhibiting their degradation. | |||||||||||||||||||||
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References
- [1]. Ito S, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.Eur J Pharmacol. 2004 Feb 23;486(3):325-33. [Content Brief]
- [3]. Kondratskyi A1, et al.Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death.Cell Death Dis. 2014 Apr 24;5:e1193. [Content Brief]
