1110670-49-9
1110670-49-9
Chemical Structure
Caspase-3/7 Inhibitor I
- CAS No.: 1110670-49-9
- Formula:C14H16N2O5S
- Molecular Weight:324.35
IUPAC Name: 5-((2-(methoxymethyl)pyrrolidin-1-yl)sulfonyl)indoline-2,3-dione
InChIKey: SLQMNVJNDYLJSF-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C=C(S(=O)(N3C(COC)CCC3)=O)C=C2)C1=O
Biological Activity: Caspase-3/7 inhibitor I is a potent and reversible inhibitor of caspase-3 and caspase-7, with Kis of 60 and 170 nM, respectively. Caspase-3/7 inhibitor I can inhibit apoptosis in Camptothecin (HY-16560)-treated Jurkat cells and in chondrocytes[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Caspase-3/7 Inhibitor I | 98.31% | Caspase-3/7 inhibitor I is a potent and reversible inhibitor of caspase-3 and caspase-7, with Kis of 60 and 170 nM, respectively. Caspase-3/7 inhibitor I can inhibit apoptosis in Camptothecin (HY-16560)-treated Jurkat cells and in chondrocytes. | ||||||||||||||||||||
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References
- [1]. Lee D, et, al. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. J Biol Chem. 2000 May 26;275(21):16007-14. [Content Brief]
- [2]. Lee D, et, al. Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44(12):2015-26. [Content Brief]
