111073-34-8
111073-34-8
Chemical Structure
OPC-4392
- CAS No.: 111073-34-8
- Formula:C24H29N3O2
- Molecular Weight:391.51
IUPAC Name: 7-(3-(4-(2,3-dimethylphenyl)piperazin-1-yl)propoxy)quinolin-2(1H)-one
InChIKey: RRLWEQBPSAFVAS-UHFFFAOYSA-N
SMILES: CC(C(C)=CC=C1)=C1N(CC2)CCN2CCCOC3=CC=C(C=CC4=O)C(N4)=C3
Biological Activity: OPC-4392 is a orally active presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. OPC 4392 reverses the Reserpine (HY-N0480)-induced dopamine accumulation, inhibits Apomorphine (HY-12723)-induced stereotypic and climbing behaviors in mouse models. OPC-4392 can be used as antipsychotic agent[1][2].
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OPC-4392 | OPC-4392 is a orally active presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. OPC 4392 reverses the Reserpine (HY-N0480)-induced dopamine accumulation, inhibits Apomorphine (HY-12723)-induced stereotypic and climbing behaviors in mouse models. OPC-4392 can be used as antipsychotic agent. | |||||||||||||||||||||
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References
- [1]. Yasuda Y, et al. 7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. Life Sci. 1988;42(20):1941-54. [Content Brief]
- [2]. Murasaki M, et al. Phase 1 study of a new antipsychotic drug, OPC-4392. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(5):793-802. [Content Brief]
