1111050-17-9
1111050-17-9
Chemical Structure
Autophagy activator-2
- CAS No.: 1111050-17-9
- Formula:C22H36N6OS
- Molecular Weight:432.63
InChIKey: KMDMOXKJZIGOMN-UHFFFAOYSA-N
SMILES: CCCCN(CC)CCCNC(C1=C(C)C2=C(N3CCN(C)CC3)N=CN=C2S1)=O
Biological Activity: Autophagy activator-2 is a potent autophagy activator with EC50 values of 14.33 μM. Autophagy activator-2 acts as a proteostasis modulator and small-molecule chaperone that upregulates I1061T mutant NPC1 expression and facilitates cholesterol efflux. Autophagy activator-2 reduces lysosomal hydrolase levels. Autophagy activator-2 can be used for the study of Niemann-Pick Type C disease[1].
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Autophagy activator-2 | Autophagy activator-2 is a potent autophagy activator with EC50 values of 14.33 μM. Autophagy activator-2 acts as a proteostasis modulator and small-molecule chaperone that upregulates I1061T mutant NPC1 expression and facilitates cholesterol efflux. Autophagy activator-2 reduces lysosomal hydrolase levels. Autophagy activator-2 can be used for the study of Niemann-Pick Type C disease. | |||||||||||||||||||||
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