111279-49-3
111279-49-3
Chemical Structure
A 65281
- CAS No.: 111279-49-3
- Formula:C17H16F2N4O2S
- Molecular Weight:378.40
IUPAC Name: 9-cyclopropyl-6,8-difluoro-7-(piperazin-1-yl)isothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione
InChIKey: DMWIKVPTLPZXQB-UHFFFAOYSA-N
SMILES: O=C1NSC(N(C2=C3C=C(C(N4CCNCC4)=C2F)F)C5CC5)=C1C3=O
Biological Activity: A 65281 is a potent DNA gyrase inhibitor with an IC50 value of 0.1 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II. A 65281 inhibits P4 DNA unknotting with an IC50 value of 8 µg/mL[1].
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A 65281 | A 65281 is a potent DNA gyrase inhibitor with an IC50 value of 0.1 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II. A 65281 inhibits P4 DNA unknotting with an IC50 value of 8 µg/mL. | |||||||||||||||||||||
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