111686-79-4
111686-79-4
Chemical Structure
Remacemide hydrochloride
Synonym(s): FPL 12924AA
- CAS No.: 111686-79-4
- Formula:C17H21ClN2O
- Molecular Weight:304.81
IUPAC Name: 2-amino-N-(1,2-diphenylpropan-2-yl)acetamide hydrochloride
InChIKey: HYQMIUSWZXGTCC-UHFFFAOYSA-N
SMILES: NCC(NC(C)(C1=CC=CC=C1)CC2=CC=CC=C2)=O.[H]Cl
Biological Activity: Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively[1]. Remacemide hydrochloride is an anticonvulsant agent[2].
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Remacemide hydrochloride | Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively. Remacemide hydrochloride is an anticonvulsant agent. | |||||||||||||||||||||
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References
- [1]. G C Palmer, et al. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann N Y Acad Sci. 1995 Sep 15;765:236-47; discussion 248. [Content Brief]
- [2]. Sarah Santangeli, et al. Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur J Pharmacol. 2002 Mar 1;438(1-2):63-8. [Content Brief]
