111745-56-3
Chemical Structure
Pediocin PA 1
- CAS No.: 111745-56-3
- Formula:C196H293N61O60S5
- Molecular Weight:4624.12
SMILES: O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=C(C=C2)O)C(NCC(N[C@@H](CC(N)=O)C(NCC(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(NCC(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(O)=O)NC5=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(NCC(NCC(N[C@@H](CC8=CNC=N8)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC9=CNC=N9)C(N[C@H]5CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%10=O)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC%11=CNC=N%11)C(N[C@H]%10CO)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Biological Activity: Pediocin PA 1 is a class IIa bacteriocin that specifically binds to membrane proteins of susceptible Gram-positive bacteria (such as Listeria monocytogenes) to form voltage-independent hydrophilic pores, leading to dissipation of proton motive force, ATP depletion and cell death. Pediocin PA 1 shows no significant activity against intact Gram-negative bacteria, strains carrying immunity genes and obligate anaerobic commensal gut microbiota, and its bactericidal function depends on the integrity of disulfide bonds, with activity lost upon reduction. Pediocin PA 1 can be used not only as a food biopreservative but also for research on listeriosis[1][2][3].
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Pediocin PA 1 | Pediocin PA 1 is a class IIa bacteriocin that specifically binds to membrane proteins of susceptible Gram-positive bacteria (such as Listeria monocytogenes) to form voltage-independent hydrophilic pores, leading to dissipation of proton motive force, ATP depletion and cell death. Pediocin PA 1 shows no significant activity against intact Gram-negative bacteria, strains carrying immunity genes and obligate anaerobic commensal gut microbiota, and its bactericidal function depends on the integrity of disulfide bonds, with activity lost upon reduction. Pediocin PA 1 can be used not only as a food biopreservative but also for research on listeriosis. | |||||||||||||||||||||
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References
- [1]. Kuniyoshi TM, et al. An oxidation resistant pediocin PA-1 derivative and penocin A display effective anti-Listeria activity in a model human gut environment. Gut Microbes. 2022;14(1):2004071. [Content Brief]
- [2]. Chikindas ML, et al. Pediocin PA-1, a bacteriocin from Pediococcus acidilactici PAC1.0, forms hydrophilic pores in the cytoplasmic membrane of target cells. Appl Environ Microbiol. 1993;59(11):3577-3584. [Content Brief]
- [3]. Rodríguez JM, et al. Pediocin PA-1, a wide-spectrum bacteriocin from lactic acid bacteria. Crit Rev Food Sci Nutr. 2002 Mar;42(2):91-121. [Content Brief]
