1117772-52-7
Chemical Structure
ABD-350
- CAS No.: 1117772-52-7
- Formula:C19H22F2O2
- Molecular Weight:320.37
IUPAC Name: 1-(2',4'-difluoro-2-methyl-[1,1'-biphenyl]-4-yl)hexane-1,6-diol
InChIKey: MLHURYYXRZMSBS-UHFFFAOYSA-N
SMILES: OC(CCCCCO)C1=CC=C(C(C)=C1)C2=CC=C(C=C2F)F
Biological Activity: ABD-350 is an antiresorptive agent that inhibits osteoclast activity without affecting osteoblast activity and preventing ovariectomy-induced bone loss. ABD-350 inhibits NF-κB ligand-induced inhibitor of NF-κB phosphorylation, leading to osteoclast apoptosis, but has no inhibitory effect on osteoblast function, effectively preventing bone loss in ovariectomized mice, and does not inhibit parathyroid hormone-induced bone formation.
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ABD-350 | ABD-350 is an antiresorptive agent that inhibits osteoclast activity without affecting osteoblast activity and preventing ovariectomy-induced bone loss. ABD-350 inhibits NF-κB ligand-induced inhibitor of NF-κB phosphorylation, leading to osteoclast apoptosis, but has no inhibitory effect on osteoblast function, effectively preventing bone loss in ovariectomized mice, and does not inhibit parathyroid hormone-induced bone formation. | |||||||||||||||||||||
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