111843-78-8
Chemical Structure
5(6)-Carboxy-2',7'-dichlorofluorescein
- CAS No.: 111843-78-8
- Formula:C21H10Cl2O7
- Molecular Weight:445.21
IUPAC Name: 2',7'-dichloro-3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid compound with 2',7'-dichloro-3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-carboxylic acid (1:1)
InChIKey: HQHFUFXNPLBIOG-UHFFFAOYSA-N
SMILES: OC(C1=CC=C(C2(OC3=O)C4=C(C=C(O)C(Cl)=C4)OC5=C2C=C(Cl)C(O)=C5)C3=C1)=O.O=C(C6=CC=C(C(O)=O)C=C67)OC87C9=C(C=C(O)C(Cl)=C9)OC%10=C8C=C(Cl)C(O)=C%10
Biological Activity: 5 (6)-Carboxy-2',7'-dichlorofluorescein is a fluorescent probe substrate that acts on MRP1 and MRP3/Mrp3, passively diffuses across cell membranes, and is actively effluxed by MRP1 in MRP1-positive cells. 5 (6)-Carboxy-2',7'-dichlorofluorescein is transported across membranes in an ATP-dependent manner, but does not stimulate ATPase activity[1][2].
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5(6)-Carboxy-2',7'-dichlorofluorescein | 99.03% | 5 (6)-Carboxy-2',7'-dichlorofluorescein is a fluorescent probe substrate that acts on MRP1 and MRP3/Mrp3, passively diffuses across cell membranes, and is actively effluxed by MRP1 in MRP1-positive cells. 5 (6)-Carboxy-2',7'-dichlorofluorescein is transported across membranes in an ATP-dependent manner, but does not stimulate ATPase activity. | ||||||||||||||||||||
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References
- [1]. Stehfest E, et al. Non-destructive micromethod for MRP1 functional assay in human lung tumor cells. Archives of toxicology. 2006 Mar;80(3):125-33.
- [2]. Chandra P, et al. Short-term regulation of multidrug resistance-associated protein 3 in rat and human hepatocytes. American journal of physiology. Gastrointestinal and liver physiology. 2005 Jun;288(6):G1252-8.
