111864-49-4
111864-49-4
Chemical Structure
2′-Deoxy-ADPR
- CAS No.: 111864-49-4
- Formula:C15H23N5O13P2
- Molecular Weight:543.32
InChIKey: QUQXNEJSUIYECI-NLWHDCMFSA-N
SMILES: O[C@H]1C[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)C(O)O4)(O)=O)(O)=O
Biological Activity: 2′-Deoxy-ADPR is an endogenous TRPM2 agonist that activates Ca2+-permeable cation channels. 2′-Deoxy-ADPR activates the Ca2+ sensitivity of TRPM2, increasing whole-cell currents by slowing inactivation and increasing open probability. 2′-Deoxy-ADPR can be used in research related to TRPM2 channel-mediated diseases, such as inflammation and immune-related diseases[1][2][3].
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2′-Deoxy-ADPR | 2′-Deoxy-ADPR is an endogenous TRPM2 agonist that activates Ca2+-permeable cation channels. 2′-Deoxy-ADPR activates the Ca2+ sensitivity of TRPM2, increasing whole-cell currents by slowing inactivation and increasing open probability. 2′-Deoxy-ADPR can be used in research related to TRPM2 channel-mediated diseases, such as inflammation and immune-related diseases. | |||||||||||||||||||||
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References
- [1]. Fliegert R, et al. 2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist. Nature chemical biology. 2017 Sep;13(9):1036-1044. [Content Brief]
- [2]. Pick J, et al. 2'-deoxy-ADPR activates human TRPM2 faster than ADPR and thereby induces higher currents at physiological Ca concentrations. Frontiers in immunology. 2024;15:1294357.
- [3]. Belrose JC, et al. TRPM2: a candidate therapeutic target for treating neurological diseases. Acta pharmacologica Sinica. 2018 May;39(5):722-732.
