1119807-02-1
1119807-02-1
Chemical Structure
AZD5213
- CAS No.: 1119807-02-1
- Formula:C19H25N3O2
- Molecular Weight:327.42
IUPAC Name: 4-((1S,2S)-2-(4-cyclobutylpiperazine-1-carbonyl)cyclopropyl)benzamide
InChIKey: VCQZCDSEWSFTPO-SJORKVTESA-N
SMILES: O=C(N)C1=CC=C([C@@H]2[C@@H](C(N3CCN(C4CCC4)CC3)=O)C2)C=C1
Biological Activity: AZD5213 is a selective and competitive human H3 receptor antagonist with a pKi value of 9.3 for hH3R. AZD5213 can be used for the research of sleep and cognitive regulation[1][2].
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AZD5213 | AZD5213 is a selective and competitive human H3 receptor antagonist with a pKi value of 9.3 for hH3R. AZD5213 can be used for the research of sleep and cognitive regulation. | |||||||||||||||||||||
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References
- [1]. Schou M, et al. Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor. ACS Chem Neurosci. 2016 Feb 17;7(2):177-84. [Content Brief]
- [2]. Nikolic K, et al. Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities. CNS Neurosci Ther. 2014 Jul;20(7):613-23. [Content Brief]
