1120333-38-1
1120333-38-1
Chemical Structure
NecroX-2
- CAS No.: 1120333-38-1
- Formula:C25H32N4O4S2
- Molecular Weight:516.68
InChIKey: OXROWZRDUZOTSG-UHFFFAOYSA-N
SMILES: O=S(N1CCC(CC1)NC2=CC(CN3CCS(=O)(CC3)=O)=CC4=C2NC(C5=CC=CC=C5)=C4)(C)=O
Biological Activity: NecroX-2 is a potent inhibitor of caspase-independent necrosis. NecroX-2 exhibits antioxidant activity by scavenging DPPH radicals and peroxynitrite. NecroX-2 inhibits t-BHP-induced mitochondrial ROS/RNS generation, and protects t-BHP and Doxorubicin (HY-15142A)-induced cell death in vitro. NecroX-2 can be used for research on neurological diseases[1][2].
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NecroX-2 | NecroX-2 is a potent inhibitor of caspase-independent necrosis. NecroX-2 exhibits antioxidant activity by scavenging DPPH radicals and peroxynitrite. NecroX-2 inhibits t-BHP-induced mitochondrial ROS/RNS generation, and protects t-BHP and Doxorubicin (HY-15142A)-induced cell death in vitro. NecroX-2 can be used for research on neurological diseases. | |||||||||||||||||||||
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References
- [1]. Kim HJ, et al. NecroX as a novel class of mitochondrial reactive oxygen species and ONOO⁻ scavenger. Arch Pharm Res. 2010;33(11):1813-1823. [Content Brief]
- [2]. Wang B, et al. BNIP3 upregulation by ERK and JNK mediates cadmium-induced necrosis in neuronal cells. Toxicol Sci. 2014;140(2):393-402. [Content Brief]
