1123155-95-2
Chemical Structure
RO5101576
- CAS No.: 1123155-95-2
- Formula:C36H38O8S
- Molecular Weight:630.75
IUPAC Name: 4-(3-(6-(3-(benzo[d][1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl)-2-(2-carboxyethyl)phenoxy)butanoic acid
InChIKey: SRPFDFNVILUDAI-UHFFFAOYSA-N
SMILES: O=C(CCCOC1=CC=CC(CCCCCCOC2=CC(C3=CSC=C3)=CC(C4=CC=C5OCOC5=C4)=C2)=C1CCC(O)=O)O
Biological Activity: RO5101576 is a potent LTB4 receptor antagonist with activity to inhibit LTB4-induced calcium mobilization and chemotaxis of human neutrophils. RO5101576 significantly attenuated LTB4-induced pulmonary eosinophilia in guinea pigs. RO5101576 inhibited allergen- and ozone-induced pulmonary neutrophilia in nonhuman primates with efficacy comparable to that of budesonide. RO5101576 had no effect on LPS-induced neutrophilia in guinea pigs and cigarette smoke-induced neutrophilia in mice and rats. RO5101576 performed well in toxicology studies and was well tolerated[1].
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RO5101576 | RO5101576 is a potent LTB4 receptor antagonist with activity to inhibit LTB4-induced calcium mobilization and chemotaxis of human neutrophils. RO5101576 significantly attenuated LTB4-induced pulmonary eosinophilia in guinea pigs. RO5101576 inhibited allergen- and ozone-induced pulmonary neutrophilia in nonhuman primates with efficacy comparable to that of budesonide. RO5101576 had no effect on LPS-induced neutrophilia in guinea pigs and cigarette smoke-induced neutrophilia in mice and rats. RO5101576 performed well in toxicology studies and was well tolerated. | |||||||||||||||||||||
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