1123163-20-1
Chemical Structure
GSK2163632A
- CAS No.: 1123163-20-1
- Formula:C27H32N8O3S
- Molecular Weight:548.66
IUPAC Name: 3-((2-((1-(dimethylglycyl)-6-methoxy-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)thiophene-2-carboxamide
InChIKey: YNSCKPCDFIDINW-UHFFFAOYSA-N
SMILES: O=C(N)C1=C(C=CS1)NC2=C3C(NC=C3)=NC(NC4=CC5=C(C(C)(CCN5C(CN(C)C)=O)C)C=C4OC)=N2
Biological Activity: GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that can be used as a probe for studying heart failure and Parkinson's disease. GSK2163632A potently inhibits GRK1 and GRK5, and also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R. GSK2163632A binds to GRK2 in a manner similar to Paroxetine (HY-122272).
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GSK2163632A | GSK2163632A is a selective G protein-coupled receptor kinase (GRK) inhibitor that can be used as a probe for studying heart failure and Parkinson's disease. GSK2163632A potently inhibits GRK1 and GRK5, and also inhibits Rho-associated coiled-coil kinase (ROCK) and insulin-like growth factor receptor IGF-1R. GSK2163632A binds to GRK2 in a manner similar to Paroxetine (HY-122272). | |||||||||||||||||||||
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