112560-33-5
Chemical Structure
Keto-itraconazole
Synonym(s): keto-ITZ
- CAS No.: 112560-33-5
- Formula:C35H36Cl2N8O5
- Molecular Weight:719.62
IUPAC Name: 4-(4-(4-(4-(((2R,4S)-2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(3-oxobutan-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one
InChIKey: GZEZATDDANETAV-QQPVTLCMSA-N
SMILES: O=C1N(N=CN1C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@@H]5O[C@](CN6N=CN=C6)(OC5)C7=CC=C(C=C7Cl)Cl)C(C)C(C)=O
Biological Activity: Keto-itraconazole (keto-ITZ) is a metabolism of Itraconazole (HY-17514) with a potent inhibitor activity of CYP3A. Keto-itraconazole shows unbound IC50 value of 4.6 nM when coincubated with human liver microsomes and midazolam[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Keto-itraconazole | 98.4% | Keto-itraconazole (keto-ITZ) is a metabolism of Itraconazole (HY-17514) with a potent inhibitor activity of CYP3A. Keto-itraconazole shows unbound IC50 value of 4.6 nM when coincubated with human liver microsomes and midazolam. | ||||||||||||||||||||
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